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Method development at the Swedish NMR Centre

NMR is a common analytical technology, but there are a number of different methods that can be used within the field. At the centre there is a concerted effort to develop methodologies, which takes place in close interaction with the researchers using the instruments.

Many researchers use NMR spectroscopy to investigate molecular structures. Others are familiar with the structure and wants to find out how materials associate or aggregate with one another.

Historically the backbone of the Swedish NMR Centre competence - Structural biology - use about 50 percent of the instrument time and involves a majority of the staff through the whole workflow from isotope labelling, sample preparation, data acquisition and analysis. However, we also offer expert assistance for applications in metabolomics, chemical biology, small molecule-NMr and material science.

Ensemble of 20 conformers of a protein with a flexible N-terminus (in blue). Structure solved by the staff at the Swedish NMR Centre in 2015. Click to enlarge image.

Research groups

At the centre there are active research groups. In short, there is currently a focus on studies of intrinsically unstructured proteins and membrane proteins. NMR optimized cell-free protein expression development is in focus as well as method development in the material science field, namely diffusion-NMR and microimaging.



Page Manager: Anders Pedersen|Last update: 1/25/2018

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Utskriftsdatum: 2018-02-21