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Máté Erdélyi group research

NMR of small molecules and weak interactions

Understanding human diseases and the molecular basis of the bioactivity of drugs used for their treatment requires a thorough elucidation of the structure and interaction mechanism of all involved compounds. Our research interest is in the application and development of NMR-based physical-organic methods for the investigation of very weak chemical interactions taking place in solution. Since most, if not all, physiological processes proceed in solution environment, such studies are expected to possess great advantages as compared to crystallographic, gaseous phase and in silico studies. Our present focus is on the energetic and geometric description of halogen bonding through investigation of various types of model systems and through their detection in drug-biopolymer complexes. Since halogen functionalities are present in approximately 50% of the candidates tested in high throughput drug screens, an improved understanding of their secondary chemical interactions could revolutionize drug design. Our interdisciplinary approach encompasses computational design, solution and solid-phase organic synthesis, kinetic experiments, and modern spectroscopic methods. A further interest of ours is the detailed structure determination of natural products as well as small, synthetic drug-candidates for development of the structure-activity relationship of major human diseases.

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Contact Information

Máté Erdélyi

Dept. of Chemistry, 41296 Gothenburg

Visiting Address:
Kemigården 4, 41296 Gothenburg

Phone:
+46 (0)31 786 9033

Fax:
+46 (0)31 772 3840

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Page Manager: Anders Pedersen|Last update: 8/30/2016
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