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Billeter group research

NMR and molecular dynamics

The ultimate goal of Structural Proteomics is to provide a “dense” set of 3D protein structures representing all gene products. The share of NMR in some of the most successful efforts today reaches up to 50%. The efficiency of all NMR steps becomes a critical issue as the protein supply increases. We develop, test and/or apply high-throughput NMR tools that (a) reduce costly instrument time (“sparse” data sampling and “reduced dimensionality”), (b) allow reliable signal identification in all types of spectra, and (c) automate the most critical step, the resonance assignment.By optimizing and streamlining all steps from the first NMR experiment to the structure calculation, NMR structure determinations will truly fulfill high-throughput requirements.

Early results for a variety of spin-offs show the usefulness of these novel approaches for topics such as drug discovery or characterization of internal dynamics. Currently, we collaborate with several European and North-American research groups. For the future we envision a local, strong research environment allowing efficient implementation and easy access of advanced NMR techniques through technical support and a critical mass of NMR researchers. A profound understanding of protein function requires 3D characterization of the protein, which is incomplete without an analysis of internal dynamics. We combine experimental and calculational approaches. Besides the inherent intimate relation between experiment and theory, NMR relaxation measurement for dynamics and computational simulations of molecular dynamics complement each other in an ideal way regarding validation, different time scales and resolution in both time and space. Current projects involve electron transfers in proteins and specificity in DNA-recognition by proteins. By streamlining experiments and their analysis and by providing easy access to all techniques involved, the characterization of protein function by NMR dynamics studies will become much more attractive to a wide user community.

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Contact Information

Martin Billeter

PO Box 462, SE-40530 Gothenburg

Visiting Address:
Dept. of Chemistry, Biochemistry and Biophysics, Medicinaregatan 9C, 41390 Gothenburg

Phone:
+46 (0)31 786 3925

Fax:
+46 (0)31 786 3910

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Page Manager: Anders Pedersen|Last update: 6/28/2010
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